"Annie Hall" has some of my favorite opening lines of any movie:
"There's an old joke. Uh, two elderly 
women are at a Catskills mountain 
resort, and one of 'em says: "Boy, the 
food at this place is really terrible." 
The other one says, "Yeah, I know, and 
such ... small portions." Well, that's 
essentially how I feel about life. Full 
of loneliness and misery and suffering 
and unhappiness, and it's all over much 
too quickly."

Via EW and Rolling Stone.